GraphProt: modeling binding preferences of RNA-binding proteins
نویسندگان
چکیده
منابع مشابه
Sequence, Structure and Context Preferences of Human RNA Binding Proteins
1. Department of Biology, MIT, Cambridge MA 2. Program in Computational and Systems Biology, MIT, Cambridge MA 3. Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 4. Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 5. Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jo...
متن کاملRNAcontext: A New Method for Learning the Sequence and Structure Binding Preferences of RNA-Binding Proteins
Metazoan genomes encode hundreds of RNA-binding proteins (RBPs). These proteins regulate post-transcriptional gene expression and have critical roles in numerous cellular processes including mRNA splicing, export, stability and translation. Despite their ubiquity and importance, the binding preferences for most RBPs are not well characterized. In vitro and in vivo studies, using affinity select...
متن کاملRNA-binding proteins.
The C. elegans genome encodes many RNA-binding proteins (RBPs) with diverse functions in development, indicative of extensive layers of post-transcriptional control of RNA metabolism. A number of C. elegans RBPs have been identified by forward or reverse genetics. They tend to display tissue-specific mutant phenotypes, which underscore their functional importance. In addition, several RBPs that...
متن کاملmicroRNAs and RNA-binding proteins
In the last decade, an ever-growing number of connections between microRNAs (miRNAs) and RNA-binding proteins (RBPs) have uncovered a new level of complexity of gene expression regulation in cancer. In this review, we examine several aspects of the functional interactions between miRNAs and RBPs in cancer models. We will provide examples of reciprocal regulation: miRNAs regulating the expressio...
متن کاملRNA-binding proteins in trypanosomes
Background: Trypanosomes mostly control gene expression by post-transcriptional events such as modulation of mRNA stability and translational efficiency. These mechanisms involve RNAbinding proteins (RBPs), which associate with transcripts to form messenger ribonucleoprotein (mRNP) complexes. Results: In this study, we report the identification of mRNA targets for Trypanosoma cruzi U-rich RBP 1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2014
ISSN: 1465-6906
DOI: 10.1186/gb-2014-15-1-r17